Crystal Links


251) M.A. Currie, G. Brown, A. Wong, T. Ohira, K. Sugiyama, T. Suzuki, A.F. Yakunin and Z. Jia. (2017) Structural and functional characterization of the TYW3/Taw3 class of SAM-dependent methyltransferases. RNA, 23, 346-354.

250) U. Boles, C. Simpson, E.E. Gul, C. Kiss, A. Enriquez, Z. Jia, A. Baranchuk and J.S. Walia. (2017) Clinical evaluation of R860Q semi-conservative amino acid substitution in CACNA1C gene in association with long QT syndrome. Int. J. Cardiol. Heart. Vasc. 15, 21-23.

249) R.Y. Cao, R. Eves, L. Jia, C.D. Funk, Z. Jia and A. Mak. (2017) Effects of p53-knockout in vascular smooth muscle cells on atherosclerosis in mice. PloS One, 12, e0175061. 

248) D. Vukomanovic, M.N. Rahman, Z. Jia and K. Nakatsu. (2017) Drug-enhanced carbon monoxide production from heme by cytochrome P450 reductase. Med. Gas. Res. 7, 37-44. 

247) X. Zhang, Y. Jiang, Q. Mao, H. Tan, X. Li, G. Chen and Z.  Jia. (2017) Distal proton shuttle mechanism of ribosome catalysed peptide bond formation - A DFT study. Molecules, 22:571. 

246) Y. Jiang, X. Zhang, Q. Mao, H. Tan, X. Li, G. Chen and Z. Jia. (2017) A theoretical study on oxidative cleavage of olefins to carbonyls catalysed by Fe(III)-PyBisulidine. Dalton Trans. 46, 3825-3832.


245) Q. Wei, S. Yang, D. Li, X. Zhang, J. Zheng and Z. Jia. (2016) A new autoinhibited kinase conformation reveals a salt-bridge switch in kinase activation. Sci. Rep. 6:28437.

244) S. Yang, H. Pei, X. Zhang, Q. Wei, J. Zhu, J. Zheng and Z. Jia. (2016) Characterization of DicB by partially masking its potent inhibitory activity of cell division. Open Biol. 6:160082.

243) Q. Ye, Y. Yang, L. van Staalduinen, S.W. Crawley, L. Liu, S. Brennan, G.P. Côté and Z. Jia. (2016) Structure of the Dictyostelium Myosin-II Heavy Chain Kinase A (MHCK-A) α-kinase domain apoenzyme reveals a novel autoinhibited conformation. Sci. Rep. 6:26634.

242) J. Qin, H. Tan, X. Li, G. Chen, J. Zheng, Y. Wang, J. Ma and Z. Jia. (2016) Theoretical studies of function switch and mechanism of AceK as a highly active ATPase. RSC Adv. 6, 68120-68127.

241) Y. Yin, S. Li, Y. Gao, L. Tong, J. Zheng, Z. Jia, G. Jiang and Q. Wei. (2016) Loopβ3αC plays an important role in the structure and function of isocitrate dehydrogenase kinase/phosphatase (AceK). FEBS Letters, 590, 3144-3154.

240) Y. Zhao, X. Yang, Z. Jia, R.L. Reid, P. Leclerc and F.W.K. Kan. (2016) Recombinant human oviductin regulates protein tyrosine phosphorylation and acrosome reaction. Reproduction, 152, 561-573.

239) P.A. Meyer, S. Socias, J. Key, ….. Z. Jia, ….. M. Crosa, P. Sliz. (2016) Data publication with the structural biology data grid supports live analysis. Nat. Commun. 7:10882.

238) D. Li, W. Wu, H. Pei, Q. Wei, J. Zheng and Z. Jia. (2016) Expression and preliminary characterization of human MICU2. Biol Open, 5, 962-969.

237) D. Vukomanovic, M.N. Rahman, M.D. Maines, T.R.S. Ozolinš, W.A. Szarek, Z. Jia and K. Nakatsu. (2016) Cysteine-independent activation/inhibition of heme oxygenase-2. Med. Gas. Res. 6, 10-13.

236) Y.H. Ouellet, C.T. Ndiaye, S.M. Gagné, A. Sébilo, M.D.L. Suits, É. Jubinville, Z. Jia, A. Ivancich and M. Couture. (2016). New insights into the heme degradation reaction by Escherichia coli O157:H7 catalyzed by ChuS. J. Inorg. Biochem. 154, 103-113.

235) W. Wu, Q. Chen, F. Geng,  L. Tong, R. Yang, J. Yang, H. Zhang, Z. Jia and Q. Wei. (2016) Calcineurin B stimulates cytokine production through a CD14-independent Toll-like receptor 4 pathway. Immunol. Cell Biol. 94, 285-292.

234) C. Chesterman and Z. Jia. (2016) Purification, characterization, and crystallization of membrane bound E. coli tyrosine kinase. Protein Expr. Purif. 125, 34-42.

233) N. Wang, X. Cheng, J. Zheng, G. Chen and Z. Jia. (2016) Expression and purification of DEPTOR and its interaction with mTOR-TRD2. Chem. J. Chinese U. 5, 912-919.


234) C. Prince and Z. Jia. (2015) An unexpected duo: Rubredoxin binds nine TPR motifs to form LapB, an essential regulator of lipopolysaccharide synthesis. Structure, 23, 1500-1506.

231) Y. Jiang, H. Tan, J. Zheng, X. Li, G. Chen and Z. Jia. (2015) Phosphoryl transfer reaction catalyzed by membrane diacylglycerol kinase: a theoretical mechanism study. Phys. Chem. Chem. Phys. 17, 25228-25234.

230) Y. Yang, Q. Ye, Z. Jia and G. Cote. (2015) Characterization of the catalytic and nucleotide binding properties of the alpha-kinase domain of Dictyostelium myosin-II heavy chain kinase A. J. Biol. Chem. 290, 23935-23946.

229) W. Wu, M.N. Rahman, J. Guo, N. Roy, L. Xue, C.M. Cahill, S. Zhang and Z. Jia. (2015) Otoferlin-GAD65 coupling and its effects on GABAergic activity. J. Mol. Cell Biol. 7, 168-179.

228) N. Wang, J. Jiang, X. Li, H. Tan, J. Zheng, G. Chen and Z. Jia. (2015) Molecular dynamics simulation studies of dTTP binding and catalysis mediated by YhdE dimerization. PloS ONE, 10, e0134879.

227)  J. Jiang, N. Wang, Y. Jiang, H. Tan, J. Zheng and Z. Jia. (2015) Characterization of substrate binding of the WW domains in human WWP2 protein. FEBS Letter, 589, 1935-1941.

226) B. Wheeler and Z. Jia. (2015) Preparation and characterization of human ADCK3, a putative atypical kinase. Protein Expr. Purif. 108, 13-17.

225) J. Jin, R. Wu, J. Zhu, S. Yang, Z. Lei, N. Wang, V.K. Singh, J. Zheng and Z. Jia. (2015) Insights into the cellular function of YhdE, a nucleotide pyrophosphatase from Escherichia coli. PloS ONE, 10, e0117823.

224) L. M. van Staalduinen and Z. Jia. (2015). Post-translational hydroxylation by 2OG/Fe(II)-dependent oxygenases as a novel regulatory mechanism in bacteria. Front. Microbiol. 5:798.

223) J. Jiang, J. Zheng, Y. She and Z. Jia. (2015) Expression and purification of human WWP2 HECT domain in Escherichia coli. Protein Expr. Purif. 110, 95-101.

222) C. Prince and Z. Jia (2015) Quantification of detergents using colorimetric methods in membrane protein crystallography. Methods Enzymol. 110, 95-101.


221) S. Wang, Q. Shen, G. Chen, J. Zheng, H. Tan and Z. Jia. (2014) Phosphatase mechanism of bifunctional kinase/phosphatase AceK. Chem. Commun. 50, 14117-14120.

220) Q. Wei, J. Liu, N. Wang, X. Zhang, J. Jin, I. Chin-Sang, J. Zheng and  Z. Jia. (2014) Structures of an Eph receptor tyrosine kinase and its potential activation mechanism. Acta Cryst. D70, 3135-3143.

219) L.M. van Staalduinen, F.R. McSorley, K. Schiessl, J. Séguin, P.B. Wyatt, F. Hammerschmidt, D.L. Zechel and Z. Jia. (2014) The crystal structure of PhnZ in complex with substrate reveals a new di-iron oxygenase mechanism for catabolism of organophosphonates. Proc. Natl. Acad. Sci. 111, 5171-5176.

218) M.J.Y. Lee, F. Faucher and Z. Jia. (2014) Growth of diffraction-quality protein crystals using a harvestable microfluidic device. Cryst. Growth Des. 14, 3179-3181.  

217) M.J.Y. Lee, D. Schep, B. McLaughlin, M. Kaufmann and Z. Jia. (2014) Structural analysis and identification of PhuS as a heme-degrading enzyme from Pseudomonas aeruginosa. J. Mol. Biol. 426, 1936-1946.

216) L.M. van Staalduinen, S.K. Novakowski and Z. Jia. (2014) Structure and functional analysis of YcfD, a novel 2-oxogluterate/ Fe2+-dependent oxygenase involved in translational regulation in E. coli. J. Mol. Biol. 426, 1896-1910.

215) N. Wang, R. Wu, X. Cheng, J. Jin, Z. Jia and J. Zheng. (2014) New insights into mTOR structure and regulation. Chin. Sci. Bull. 59, 2927-2935.

214) Z. Jia. (2014) Protein superglue that holds VWF together. Blood, 123, 1771-1772.

213) D. Vukomanovic, M.N. Rahman, Y. Bilokin, A.G. Golub, J.F. Brien, W.A. Szarek, Z. Jia and K. Nakatsu. (2014) In vitro activation of heme oxygenase-2 by menadione and its analogs. Med. Gas Res. 4:4.


212) J. Zheng and Z. Jia. (2013) Tiny enzyme uses context to succeed. Nature, 497, 445-446.

211) C. Prince and Z. Jia. (2013) Detergent quantification in membrane protein samples and its application to crystallization experiments. Amino Acids, 45, 1293-1302.

210) Q. Ye, Y. Feng, Y. Yin, F. Faucher, M.A. Currie, M.N. Rahman, J. Jin, S. Li, Q. Wei and Z. Jia. (2013) Structural basis of calcineurin activation by calmodulin. Cell Signal. 25, 2661-2667.

209) Q. Li, J. Zheng, H. Tan, X. Li, G. Chen and Z. Jia. (2013) Unique kinase catalytic mechanism of AceK with a single magnesium ion. PloS ONE, 8, e72048.

208) M.A. Currie, K. Cameron, F.M.V. Dias, H.L. Spencer, E.A. Bayer, C. M.G.A. Fontes, S.P. Smith and Z. Jia. (2013) Small angle X-ray scattering analysis of Clostridium thermocellum cellulosome N-terminal complexes reveals a highly dynamic structure. J. Biol. Chem. 288, 7978-7985.

207) B. Wahten and Z. Jia. (2013) A hierarchical order within protein structures underlies large separations between strands in β-sheets. Proteins, 81, 163-175.

206) M.N. Rahman, D. Vukomanovic, J.Z. Vlahakis, W.A. Szarek, K. Nakatsu and Z. Jia. (2013). Structural insights into human heme oxygenase-1 inhibition by potent and selective azole-based compounds. J. R. Soc. Interface, 10, 20120697.


205) C. Prince and Z. Jia. (2012) Measurement of detergent concentration using 2,6-dimethylphenol in membrane-protein crystallization. Acta Cryst. D68, 1694-1696.

204) F. Faucher and Z. Jia. (2012) High-resolution structure of AKR1a4 in apo form and its interaction with ligands. Acta Cryst. F68, 1271-1274.

203) V.K. Singh, Kim Munro and Z. Jia. (2012) A novel calmodulin - b-PIX interaction and its implication in receptor tyrosine kinase regulation. Cell Signal. 24, 1790-1796.

202) M.A. Currie, J.J. Adams, F. Faucher, E.A. Bayer, Z. Jia and S.P. Smith. (2012) Scaffoldin conformation and dynamics revealed by a ternary complex from the Clostridium thermocellum cellulosome. J. Biol. Chem. 287, 26953-26961.

201) F. Faucher, S. Doublie and Z. Jia. (2012) 8-Oxoguanine DNA glycosylases: one lesion, three subfamilies. Int. J. Mol. Sci. 13, 6711-6729.

200) V.K. Singh, M.N. Rahman, K. Munro, V.N. Uversky, S.P. Smith and Z. Jia. (2012) Free cysteine modulates the conformation of human C/EBP homologous protein. PLoS ONE, 7, e34680.

199) J. Zheng, S. Yates and Z. Jia. (2012) Structural and mechanistic insights into the bifunctional enzyme isocitrate dehydrogenase kinase/phosphatase AceK. Philos. Trans. R. Soc. Lond. B Biol. Sci. 367, 2656-2668.

198) M.N. Rahman, J.Z. Vlahakis, D. Vukomanovic, W. Lee, W.A. Szarek, K. Nakatsu and Z. Jia. (2012) A novel, "double-clamp" binding mode for human heme oxygenase-1 inhibition. PLoS ONE, 7, e29514.


196) B. Wathen, D.A. Pratt and Z. Jia. (2011) Hyperconjugation contributes to the bimodal distribution of glycine conformations observed in protein three-dimensional structures. ChemBioChem, 12, 1674-1677.

195) D. Vukomanovic, B.E. McLaughlin, M.N. Rahman, W.A. Szarek, J.F. Brien, Z. Jia and K. Nakatsu. (2011) Selective activation of heme oxygenase-2 by menadione. Can. J. Physiol. Pharmacol. 89, 861-864.

194) S. He, M. Wathier, K. Podzelinska, M. Wong, F. McSorely, A. Asfaw, B. Hove-Jensen, Z. Jia and D.L. Zechel. (2011). Structure and mechanism of PhnP, a phosphodiesterase from the carbon-phosphorus lyase pathway. Biochemistry, 50, 8603-8615.

193) S.W. Crawley, M. Samimi, Q. Ye, Y. Yang, B. Raveh, O. Schueler-Furman, Z. Jia and G.P. Cote. (2011) Autophosphorylation activates Dictyostelium myosin II heavy chain kinase A by providing a ligand for an allosteric binding site in the a-kinase domain. J. Biol. Chem. 286, 2607-2616.

192) J.Z. Vlahakis, M.N. Rahman, G. Roman, Z. Jia, K. Nakatsu and W.A. Szarek. (2011) Rapid, convenient method for screening imidazole-containing compounds for heme oxygenase inhibition. J. Pharmacol. Toxicol. Methods, 63, 79-88.


191) J. Zheng and Z. Jia. (2010) Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase. Nature, 465, 961-965.

190) B. Wathen and Z. Jia. (2010) Protein b-sheet nucleation is driven by local modular formation. J. Biol. Chem. 285, 18376-18384.
189) J. Hong, Y. Hu, C. Li, Z. Jia, B. Xia and C. Jin. (2010) NMR characterizations of the ice binding surface of an antifreeze protein. PLoS ONE, 5, e15682.

188) L.M. van Staalduinen, C.S. Park, S.J. Yeom, M.A. Adams-Cioaba, D.K. Oh and Z. Jia. (2010) Structure based annotation of a novel sugar isomerase from the pathogenic E. coli O157:H7. J. Mol. Biol. 401, 866-881.

187) Y.-M. She, X. Xu, A.F. Yakunin, S. Dhe-Paganon, L.J. Donald, K.G. Standing, D. C. Lee, Z. Jia and T.D. Cyr. (2010) Mass spectrometry following mild enzymatic digestion reveals phosphorylation of recombinant proteins in Escherichia coli through mechanisms involving direct nucleotide binding. J. Proteome Res. 9, 3311-3318.

186) K. Podzelinska, R. Latimer, A. Bhattacharya, L.C. Vining, D.L. Zechel and Z. Jia. (2010) Chloramphenicol biosynthesis: The structure of CmlS, a flavin-dependent halogenase with a covalently bound flavin. J. Mol. Biol. 397, 316-331.

185) Q. Ye, S.W. Crawley, Y. Yang, G.P. Cote and Z. Jia. (2010) Crystal structure of the a-kinase domain of Dctyostelium myosin heavy chain kinase A. Sci. Signal. 3, ra17.

184) J.J. Adams, M.A. Currie, E.A. Bayer, Z. Jia and S.P. Smith. (2010) Insights into higher order organization of the cellulosome revealed by a dissect-and-build approach: Crystal structure of interacting Clostridium thermocellum multimodular components. J. Mol. Biol. 396, 833-839.

183) M.A Currie, J.J Adams, S. Ali, S.P Smith and Z. Jia. (2010) Purification and crystallization of a multimodular heterotrimeric complex containing both type-I and type-II cohesin-dockerin interactions from the cellulosome of Clostridium thermocellum. Acta Cryst. F66, 327-329.

182) R. Gordienko, H. Ohno, V.K. Singh, Z. Jia, J.A. Ripmeester and V.K. Walker. (2010) Towards a green hydrate inhibitor: Imaging antifreeze proteins on clathrates. PLoS ONE 5, e8953.

181) M.N. Rahman, J.Z. Vlahakis, G. Roman, D. Vukomanovic, W.A. Szarek, K. Nakatsu and Z. Jia. (2010) Structural characterization of human heme oxygenase-1 in complex with azole-based inhibitors. J. Inorg. Biochem. 104, 324-330.

180) Y. Zhang, H. Tan, G. Chen and Z. Jia. (2010) Investigating the disorder-order transition of calmodulin binding domain upon binding calmodulin using molecular dynamics simulation. J. Mol. Recognit. 23, 360-368.

179) B. Wathen and Z. Jia. (2010) Residue patterning in helix interiors. Biochem. Cell Biol. 88, 325-327.

178) B. Wathen, Z. Jia and V.K. Walker. (2010) Modeling the interactions between poly(N-vinylpyrrolidone) and gas hydrates: Factors involved in suppressing and accelerating hydrate growth. Lect. Notes Comput. Sci. 5976, 117-133.

177) D. Vukomanovic, B. McLaughlin, M.N. Rahman, J.Z. Vlahakis, G. Roman, R.A. Dercho, R.T. Kinobe, J.F. Brien, Z. Jia, W.A. Szarek and K. Nakatsu. (2010) Recombinant truncated and microsomal heme oxygenase-1 and -2: Differential sensitivity to inhibitors. Can. J. Physiol. Pharmacol. 88, 480-486.

176) G. Roman, M.N. Rahman, D. Vukomanovic, Z. Jia, K. Nakatsu and W.A. Szarek. (2010) Heme oxygenase inhibition by 2-oxy-substituted 1-azolyl-4-phenylbutanes: Effect of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone. Chem. Biol. Drug Des. 75, 68-90.


175) D. Lee and Z. Jia. (2009) Emerging structural insights into bacterial tyrosine kinases. Trends Biochem. Sci. 34, 351-357.

174) M.A. Currie, F. Merino, T. Skarina, A.H.Y. Wong, A. Singer, G. Brown, A. Savchenko, A. Caniuguir, V. Guixe, A.F. Yakunin and Z. Jia. (2009) ADP-dependent 6-phosphofructokinase from Pyrococcus horikoshii OT3: Structure determination and biochemical characterization of Ph1645. J. Biol. Chem. 284, 22664-22671.

173) J. Zheng, A.X. Ji and Z. Jia. (2009) Purification, crystallization and preliminary X-ray analysis of bifunctional isocitrate dehydrogenase kinase/phosphatase in complex with its substrate isocitrate dehydrogenase in Escherichia coli. Acta Cryst. F65, 1153-1156.

172) A. Matte, G. Kozlov, J.-F. Trempe, M.A. Currie, D. Burk, Z. Jia, K. Gehring, I. Ekiel, A.M. Berghuis and M. Cygler. (2009) Preparation and characterization of bacterial protein complexes for structural analysis. In Advances in Protein Chemistry and Structural Biology (Elsevier), 76, 1-42.

171) T. Lu, H. Tan, D. Lee, G. Chen and Z. Jia. (2009) New insights into the activation of Escherichia coli tyrosine kinase revealed by molecular dynamics simulation and biochemical analysis. Biochemistry, 48, 7986-7995.

170) M.N. Rahman, J.Z. Vlahakis, D. Vukomanovic, W.A. Szarek, K. Nakatsu and Z. Jia. (2009) X-ray crystal structure of human heme oxygenase-1 with (2R, 4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4[{(5-trifluoromethyl-pyridin-2-yl)thio}methyl]-1,3-dioxolane: A novel, inducible binding mode. J. Med. Chem. 52, 4949-4950.

169) J. Guo, H. Massaeli, J. Xu, Z. Jia, J.T. Wigle, N. Mesaeli and S. Zhang. (2009) Extracellular potassium concentration controls cell surface hERG channel density. J. Clin. Invest. 119, 2745-2757.

168) B. Wathen and Z. Jia. (2009) Folding by numbers: The statistics of primary sequences and their use in studying protein folding. Int. J. Mol. Sci. 10, 1567-1589.

167) K. Podzelinska, S.-M. He, M. Wathier, A. Yakunin, M. Proudfoot, B. Hove-Jensen, D.L. Zechel and Z. Jia. (2009) Structure of PhnP: A phosphodiesterase of the carbon-phosphorous lyase pathway for phosphonate degradation. J. Biol. Chem. 284, 17216-17226.

166) J. Zheng, D. Lee and Z. Jia. (2009) Purification, crystallization and preliminary X-ray analysis of isocitrate dehydrogenase kinase/phosphatase in Escherichia coli. Acta Cryst. F65, 536-539.

165) M.D.L. Suits, J. Lang, G.P. Pal, M. Couture and Z. Jia. (2009) Structure and heme binding properties of Escherichia coli O157:H7 ChuX. Protein Sci.18, 825-838.

164) J.Z. Vlahakis, M. Hum, M.N. Rahman, Z. Jia, K. Nakatsu and W.A. Szarek. (2009) Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: Effect of substituents at the 4-position of the dioxolane ring. Bioorg. Med. Chem. 17, 2461-2475.

163) T.G Wright, V. Singh, J.J. Li, J. Foley, F.R. Miller, Z. Jia and B.E. Elliott. (2009) Increased production and secretion of HGF alpha-chain and an antagonistic HGF fragment in a human breast cancer progression model. Int. J. Cancer, 125, 1004-1015.

162) R. Latimer, K.Podzelinska A. Soares, A. Bhattacharya, L.C. Vining, Z. Jia and D. Zechel. (2009) Expression, purification and preliminary diffraction studies of CmlS. Acta Cryst. F65, 260-263  

161) A. Matte, I. Ekiel, Z. Jia, K. Gehring and M. Cygler. (2009) A medium-throughput structural proteomics approach applied to the genome of E. coli. In Sytstems Biology and Biotechnology of Escherichia coli (Ed. S. Y. Lee). pp. 59-79, Springer.

160) V.A. McPherson, S. Everingham, R. Karisch, J.A. Smith, C.M. Udell, J. Zheng, Z. Jia and A.W.B. Craig. (2009) Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcεRI pathway in mast cells. Mol. Cell. Biol. 29, 389-401.


159) D. Lee, J. Zheng, Y.-M. She and Z. Jia. (2008) Structure of Escherichia coli tyrosine kinase Etk reveals novel activation mechanism. EMBO J. 27, 1758-1766.

158) L. Qin, J. Zheng, C.E. Grant, Z. Jia, S. P. C. Cole and R.G. Deeley. (2008) Residues responsible for the asymmetric function of the nucleotide binding domains of Multidrug Resistance Protein (MRP) 1. Biochemistry, 47, 13952-13965.

157) M.N. Rahman, J.Z. Vlahakis, W.A. Szarek, K.Nakatsu and Z. Jia. (2008) X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1h-imidazol-1-yl)ethanone: A common binding mode for imidazole-based heme oxygenase-1 inhibitors. J. Med. Chem. 51, 5943-5952.

156) Z. Jia. (2008) TAFI: Structured for self-destruction. Blood, 112, 2597-2598.

155) V.K. Singh, I. Pacheco, V. N. Uversky, S.P. Smith, R.J. MacLeod and Z. Jia. (2008) Intrinsically disordered human C/EBP homologous protein regulates biological activity of colon cancer cells during calcium stress. J. Mol. Biol. 380, 313-326. 

154) M.D Suits, P. Sperandeo, G. Deho, A. Polissi and Z. Jia. (2008) Novel structure of the conserved Gram-negative lipopolysaccharide transport protein LptA and mutagenesis analysis. J. Mol. Biol. 380, 476-488.

153) Q. Ye, H. Wang, J. Zheng, Q. Wei and Z. Jia. (2008) The complex structure of calmodulin bound to a calcineurin peptide. Proteins, 73, 19-27.

152) K. Podzelinska, S.-M. He, D. Zechel, B. Hove-Jensen and Z. Jia. (2008) Expression, purification and preliminary diffraction studies of PhnP. Acta Cryst. F64, 554-557.

151) Y. Zhang, H. Tan, Z. Jia and G. Chen. (2008) Ligand-induced dimer formation of calmodulin. J. Mol. Recognit. 21, 267-274.

150) Y. Zhang, H. Tan, Y. Lu, Z. Jia and G. Chen. (2008) Ca2+ dissociation from the C-terminal EF-hand pair in calmodulin: A steered molecular dynamics study. FEBS Letters, 582, 1355-1361.

149) B. Wathen and Z. Jia. (2008) The local and non-local environments around cis peptides. J. Proteome Res. 7, 145-153.

148) V.K. Singh and Z. Jia. (2008) Targeting g-synuclein to counteract drug resistance in cancer. Expert Opin. Ther. Targets, 12, 59-68.

147) M.A. Adams, Y. Luo, B. Hove-Jensen, S.-M. He, L.M. van Staalduinen, D.L. Zechel and Z. Jia. (2008) Crystal Structure of PhnH: An essential component of carbon-phosphorus lyase in Escherichia coli. J. Bacteriol. 190, 1072-1083.

146) H. Xu, S. Perumal, J. Zhao, N. Du, Z. Jia, X.-Y. Liu and J.R. Lu. (2008) Interfacial adsorption of antifreeze proteins: A neutron reflection study. Biophys. J. 94, 4405-4413.

145) M.D.L. Suits, A. Matte, Z. Jia and M. Cygler. (2008) The contribution of structural proteomics to understanding the function of hypothetical proteins. In Structural Proteomics and Its Impact on the Life Sciences (J. Sussman and I. Silman, Eds.). pp. 135-152. World Scientific Publishing, Singapore.


144) J. Zheng, C. He, V. K. Singh, N.L. Martin and Z. Jia. (2007) Crystal structure of a novel prokaryotic Ser/Thr kinase and its implication in the Cpx stress response pathway. Mol. Mircobiol. 63, 1360-1371. 

143) L.M van Staalduinen, A. Bhattacharya, K. Groom, D.L. Zechel and Z. Jia.(2007) Expression, purification, and preliminary X-ray diffraction studies of RebC. Acta Cryst. F63, 980-982.

142) M.A. Adams, M.D.L. Suits, J. Zheng and Z. Jia. (2007) Piecing together the structure-function puzzle: Experiences in structure-based functional annotation of hypothetical proteins. Proteomics, 7, 2920-2932.

141) Q. Ye, H. Wang, A. Wong, X. Li, Q. Wei and Z. Jia. (2007) Crystallization characteristics of calmodulin in complex and fused with calcineurin peptide. Cryst. Growth Des. 7, 2198-2201.

140) A. Matte, Z. Jia, J. Sivaraman and M. Cygler. (2007) Insights into the biology of Escherichia coli through structural proteomics. J. Struct. Funct. Genomics, 8, 45-55.

139) V.K. Singh, Y. Zhou, J.A. Marsh, V.N. Uversky, J.D. Forman-Kay, J. Liu and Z. Jia. (2007) Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to anti-microtubule drugs. Cancer Res. 67, 626-633.

138) V.K. Singh, S. Nurmohamed, S.K. Davey and Z. Jia. (2007) Tri-cistronic cloning, overexpression and purification of human Rad9, Rad1, Hus1 protein complex. Protein Expr. Purif. 54, 204-211.

137) Y. Zhou, Y. Zhang, H. Tang, Z. Jia and G. Chen. (2007) Role of threonine on antifreeze activity of insect antifreeze protein. Chem. J. Chinese Universities, 28, 526-529.


136) M.D.L. Suits, N. Jaffer and Z. Jia. (2006) Structure of the Escherichia coli O157: H7 heme oxygenase ChuS in complex with heme and enzymatic inactivation by mutation of the heme coordinating residue His193. J. Biol. Chem. 281, 36776-36782.

135) T.S. Gujral, V.K. Singh, Z. Jia and L.M. Mulligan (2006). Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2B. Cancer Res. 66, 10741-10749.

134) J.A. Marsh, V.K. Singh, Z. Jia and J.D. Forman-Kay. (2006) Sensitivity of secondary structure propensities to sequence differences between a- and g-synuclein: Implications for fibrillation. Protein Sci. 15, 2795-2804.

133) M.A. Adams, V.K. Singh, B.O. Kelly and Z. Jia. (2006) Structural and biochemical characterization of gentisate 1,2-dioxygenase from Escherichia coli O157:H7. Mol. Microbiol. 61, 1469-1484.

132) M.A. Adams and Z. Jia. (2006) Modulator of Drug Activity B from Escherichia coli: Crystal structure of a prokaryotic homologue of DT-diaphorase. J. Mol. Biol. 359, 455-465.

131) Q. Ye, X. Li, A. Wong, Q. Wei and Z. Jia. (2006) Structure of calmodulin bound to calcineurin peptide: A new way of making an old binding mode. Biochemistry, 45, 738-745. 

130) J. Adams, G.P. Pal, Z. Jia and S. Smith. (2006) Mechanism of bacterial cell surface attachment revealed by the structure of cellulosomal type II cohesin-dockerin complex. Proc. Natl. Acad. Sci. 103, 305-310.

129) D.E. Prosser, Y. Ding, Z. Jia and G. Jones. (2006) Structural motif-based homology modeling of CYP27A1 and site-directed mutational analyses affecting vitamin D hydroxylation. Biophys. J. 90, 3389-3409.

128) C.S. Strom, X.Y. Liu and Z. Jia. (2006) Structural basis of antifreeze action. Biophys. Rev. Lett. 1, 259-270.

127) Y. Zhou, H. Tang, Z. Jia, R. Liu and G. Chen. (2006) Molecular basis for antifreeze activity difference of two insect antifreeze protein isoforms. Sci. China, B50, 266-271.


126) M.D.L. Suits, G.P. Pal, K. Nakatsu, A. Matte, M. Cygler and Z. Jia. (2005) Identification of an Escherichia coli O157:H7 heme oxygenase with tandem functional repeats. Proc. Natl. Acad. Sci. 102, 16955-16960.

125) J. Zheng, V.K. Singh and Z. Jia. (2005) Identification of an ITPase/XTPase in E. coli by structural and biochemical analysis. Structure, 13, 1511-1520.

124) M.A. Adams and Z. Jia. (2005) Structural and biochemical analysis reveal pirins to possess quercetinase activity. J. Biol. Chem. 280, 28675-28682.

123) M.A. Adams and Z. Jia. (2005) Structural and biochemical evidence for an enzymatic quinone redox cycle in Escherichia coli: Identification of a novel quinol monooxygenase. J. Biol. Chem. 280, 8358-8363.

122) C.S. Strom, X.-Y. Liu and Z. Jia. (2005) Ice surface reconstruction as AFP-induced morphological modification mechanism. J. Am. Chem. Soc. 127, 428-440.

121) W. Wu, Z. Jia, P. Liu, Z. Xie and Q. Wei. (2005) A novel PCR strategy for high-efficiency, automated site-directed mutagenesis. Nucleic Acids Res. 33, e110.

120) J.-S. Shen, V. Geoffroy, S. Neshat, Z. Jia, A. Meldrum, J.-M. Meyer and K. Poole. (2005) FpvA-mediated ferric pyoverdine uptake in Pseudomonas aeruginosa: Identification of aromatic residues in FpvA implicated in ferric pyoverdine binding and transport. J. Bacteriol. 187, 8511-8515.

119) C.S. Strom, X.-Y. Liu and Z. Jia. (2005) Why does insect AFP from Tenebrio molitor (TmAFP) produce pyramidal ice crystallites? Biophys. J. 89, 2618-2627.

118) Q. Ye, I. Imriskova-Sosova B.C. Hill and Z. Jia. (2005) Identification of a disulfide switch in BsSco, a member of the Sco family of cytochrome c oxidase assembly proteins. Biochemistry, 44, 2934-2942.

117) W. Sangrar, R. Zirngibl, Y. Gao, W. Muller, Z. Jia and P. Greer. (2005) An identity crisis for fps/fes: Oncogene or tumor-suppressor? Cancer Res. 65, 3518-3522.

116) V. Singh and Z. Jia. (2005) Refolding and one-step purification of recombinant human ARA70 over-expressed in Escherichia coli. Protein Expr. Purif. 39, 283-287.

115) M.A. Adams, C.M. Udell, G.P. Pal and Z. Jia. (2005) MraZ from Escherichia coli: Cloning, purification, crystallization and preliminary X-ray analysis. Acta Cryst. F61, 378-380.

114) K. Liu, Z. Jia, G. Chen, C. Tung and R. Liu. (2005) Systematic size study of an insect antifreeze protein and its interaction with ice. Biophys. J. 88, 953-958.

113) M.A. Adams, P. Iannuzzi and Z. Jia. (2005) MdaB from Escherichia coli: cloning, purification, crystallization and preliminary X-ray analysis. Acta Cryst. F61, 235-238.

112) C. Li, C. Guo, Z. Jia, B. Xia and C. Jin. (2005) Solution structure of an antifreeze protein CfAFP-501 from Choristoneura fumiferana. J. Biomol. NMR, 32, 251-256.

111) A.R. Belczewski, J. Ho, F.B. Taylor Jr., M.B. Boffa, Z. Jia and M.L. Koschinsky. (2005) Baboon lipoprotein(a) does not bind to lysine or fibrin despite the presence of a strong lysine-binding site in apolipoprotein(a) kringle IV type 10. Biochemistry, 44, 555-564.

110) Q. Ye, V. Singh, J. Blonde and Z. Jia. (2005) Crystallization and preliminary X-ray analysis of the GST fused human Bri3 N-terminal domain. Acta Cryst. F61, 62-64.

109) P. Liu, C, Huang, Z. Jia, F. Yi, D-Y. Yu and Q. Wei. (2005) Non-catalytic domains of subunit A negatively regulate the activity of calcineurin. Biochimie. 87, 215-221.

108) J.J. Adams, G. Pal, K. Yam, H.L. Spencer, Z. Jia and S.P. Smith. (2005) Purification and crystallization of a tri-modular complex of the type II cohesin-dockerin interaction from the cellulosome of Clostridium thermocellum. Acta Cryst. F61, 46-48.

107) B. Wathen and Z. Jia. (2005) Controlling the freezing process with antifreeze proteins. In Emerging Technologies for Food Processing (D. Sun, Ed.), pp. 653-672, Elsevier Science, Amsterdam.

106) X.-J. Xie, Z. Jia and Q. Wei. (2005) Antifreeze protein structure and antifreeze mechanism. Chin. J. Cell Biology, 27, 5-8.


105) C.M. Hosfield, J.S. Elce and Z. Jia. (2004) Activation of calpain by Ca2+: Roles of the large subunit N-terminal and domain III-IV linker peptides. J. Mol. Biol. 343, 1049-1053.

104) C.S. Strom, X.-Y. Liu and Z. Jia. (2004) AFP-induced morphological modification mechanisms linked to ice binding surface and crystal facets in periodic bond chain theory. J. Biol. Chem. 279, 32407-32417.

103) T.G. Wright, J. Tsai, Z. Jia and B.E. Elliott. (2004) Inhibition by copper(II) binding of hepatocyte growth factor interaction with its receptor Met and blockade of HGF/Met function. J. Biol. Chem. 279, 32499-32506.

102) B. Wathen, M. Kuiper, V. Walker and Z. Jia. (2004) New simulation model of multi-component crystal growth and inhibition. Chemistry, 7, 1598-1605.

101) T. Moldoveanu, Z. Jia and P.L. Davies (2004) Calpain activation by cooperative Ca2+ binding at two non-EF-hand sites. J. Biol. Chem. 279, 5088-5099.

100) A.K. Larsen, T. De Veyra, Z. Jia, A. Wells, P. Dutt and J.S. Elce. (2004) Expression of human, mouse, and rat m-calpains in E. coli and in murine fibroblasts. Protein Expr. Purif. 33, 246-255.

99) Z. Yang, Z. Jia, R. Liu and G. Chen. (2004) Molecular and quantum mechanical studies on the dimerization of a b-helical antifreeze protein. Sci. China, B47, 34-40.


98) G.P. Pal, T. De Veyra, J.S. Elce and Z. Jia. (2003) Crystal structure of a μ-like calpain reveals a partially activated conformation with low Ca2+ requirement. Structure, 11, 1521-1526.

97) D. Lee. M. Cortrill, C. Forsberg and Z. Jia. (2003) Functional insights revealed by the crystal structures of Escherichia coli glucose-1-phosphatase. J. Biol. Chem. 33, 31412-31418.

96) Z. Yang, Y. Zhou, K. Liu, Y. Cheng, R. Liu, G. Chen and Z. Jia. (2003) Computational study on the function of water within a b-helix antifreeze protein dimer and in the process of ice-protein binding. Biophys. J. 85, 2599-2605.

95) B.Q. Xiang, Z. Jia, F.X. Xiao, K. Zhou, P. Liu and Q. Wei. (2003) The role of loop 7 in mediating calcineurin regulation. Protein Eng. 16, 795-798.

94) I. Sosova, Q. Ye, B.C. Hill and Z. Jia. (2003) Purification, crystallization and preliminary X-ray analysis of a Sco1-like protein from Bacillus subtilis, a copper binding protein involved in the assembly of cytochrome c oxidase. Acta Cryst. D59, 1299-1301.

93) T. Moldoveanu, C.M. Hosfield, D. Lim, Z. Jia and P.L. Davies. (2003) Calpain silencing by a reversible intrinsic mechanism. Nat. Struct. Biol. 10, 371-378.

92) A. Matte, J. Sivaraman, I. Ekiel, K. Gehring, Z. Jia and M. Cygler. (2003) The contribution of structural genomics to understanding the biology of Escherichia coli. J. Bacteriol. 185, 3994-4002.

91) S.D. Smith, Z. Jia, K.K. Huynh, A. Wells and J.S. Elce. (2003) Glutamate substitutions at a PKA consensus site are consistent with inactivation of calpain by phosphorylation. FEBS Letter, 542, 115-118.

90) B. Wathen, M. Kuiper, V. Walker and Z. Jia. (2003) A new model for simulating 3D crystal growth and its application to the study of antifreeze proteins. J. Am. Chem. Soc. 125, 729-737.

89) E. K. Leinala, J.S.C. Arthur, P. Grochulski, P.L. Davies, J.S. Elce and Z. Jia. (2003) A second binding site revealed by C-terminal truncation of calpain small subunit, a penta-EF-hand protein. Proteins, 53, 649-655.

88) S.P. Graether, S.M. Gagne, L. Spyracopoulos, Z. Jia, P.L. Davies and B.D. Sykes. (2003) Spruce budworm antifreeze protein: Changes in structure and dynamics at low temperature. J. Mol. Biol. 327, 1155-1168.

87) B.C. Hill, L. Becker, V. Anand, A. Kusmierczyk, S. M. Marcovina, M.N. Rahman, B.R. Gabel, Z. Jia, M.B. Boffa and M.L. Koschinsky. (2003) A role for apolipoprotein(a) in protection of the low-density lipoprotein component of lipoprotein(a) from copper-mediated oxidation. Arch. Biochem. Biophys. 412, 186-195.

86) G.P. Pal, T. DeVeyra, J.S. Elce and Z. Jia. (2003) Purification, crystallization and preliminary X-ray analysis of a μ-like calpain. Acta Cryst. D59, 369-371.

85) D. Lee and Z. Jia. (2003) Structure and function of Escherichia coli glucose-1-phosphatase. Recent Res. Devel. Mol. Biol. 1, 251-261.

84) B. Wathen, M. Kuiper, V. Walker and Z. Jia. (2003) Three-dimensional simulation of ice growth in the presence of antifreeze proteins. Can. J. Phys. 81, 39-45.


83) E.K. Leinala, P.L. Davies, D. Doucet, M.G. Tyshenko, V. Walker and Z. Jia. (2002) A b-helical antifreeze protein isoform with increased activity: Structural and functional insights. J. Biol. Chem. 277, 33349-33352.

82) E.K. Leinala, P.L. Davies and Z. Jia. (2002) Crystal structure of b-helical spruce budworm antifreeze protein shows intimate surface complementarity to ice. Structure, 10, 619-627.

81) Z. Jia and P.L. Davies. (2002) Antifreeze proteins: An unusual receptor-ligand interaction. Trends Biochem. Sci. 27, 101-106.

80) D. Lim and Z. Jia. (2002) Heavy metal-mediated crystallization of Escherichia coli phytase and analysis of bridging interactions. Protein Pept. Lett. 4, 359-365.

79) Y. Cheng, Z. Yang, H. Tan, R. Liu G. Chen and Z. Jia. (2002) Analysis of ice-binding sites in fish type II antifreeze protein by quantum mechanics. Biophys. J. 83, 2202-2210.

78) P. Dutt, C.N. Spriggs, P.L. Davies, Z. Jia and J.S. Elce. (2002) Origins of the difference in Ca2+ requirement for activation of m- and m-calpain. Biochem. J. 367, 263-269.

77) T. Moldoveanu, C.M. Hosfield, D. Lim, J.S. Elce, Z. Jia and P.L. Davies. (2002) A Ca2+ switch aligns the active site of calpain. Cell, 108, 649-660.

76) Y. Liu, X. Zhang, W. Zhang, Z, Chen, T, Chan, K, Ali, Z. Jia and J. Xiang. (2002) Adenovirus-mediated CD40 ligand gene-engineered dendritic cells elicit enhanced CD8(+) cytotoxic T-cell activation and antitumor immunity. Cancer Gene Ther. 9, 202-208.

75) M.E. Daley, L. Spyracopoulos, Z. Jia, P.L. Davies and B.D. Sykes. (2002) Structure and dynamics of a b-helical antifreeze protein. Biochemistry, 41, 5515-5525.

74) H. Shiraha, A. Glading, Z. Jia and A. Wells. (2002) Activation of m-calpain (calpain II) by epidermal growth factor is limited by PKA phosphorylation of m-calpain. Mol. Cell. Biol. 22, 2716-2727.

73) E.K. Leinala, P.L. Davies and Z. Jia. (2002) Elevated temperature and tyrosine iodination aid in the crystallization and structure determination of an antifreeze protein. Acta Cryst. D58, 1081-1083.

72) M.N. Rahman, L. Becker, V. Petrounevitch, B.C. Hill, Z. Jia and M.L. Koschinsky. (2002) Comparative analyses of the lysine binding site properties of apolipoprotein(a) kringle IV types 7 and 10. Biochemistry, 41, 1149-1155.

71) Z. Jia, C.M. Hosfield, P.L. Davies and J.S. Elce. (2002) Crystal structure of calpain and insights into Ca2+-dependent activation. Methods Mol. Biol. 172, 51-67.

70) Z. Jia. (2002) Computational studies of ice-binding sites of fish type II and III antifreeze proteins. Recent Res. Devel. Biophys. 1, 15-30.


69) G.P. Pal, J.S. Elce and Z. Jia. (2001) Dissociation and aggregation of calpain in the presence of calcium. J. Biol. Chem. 276, 47233-47238.

68) Z. Jia, Q. Ye, A.N. Dinaut, Q. Wang, D. Waddleton, P. Payette, C. Ramachandran, G. Hum and S.D. Taylor. (2001) Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics. J. Med. Chem. 44, 4584-4594.

67) Q. Ye, M.N. Rahman, M.L. Koschinsky and Z. Jia. (2001) High-resolution crystal structure of apolipoprotein (a) kringle IV type 7: Insights into ligand binding. Protein Sci. 10, 1124-1129.

66) Q. Ye, D. Hyndman, N. Green, X. Li, B. Korithoski, Z. Jia and T.G. Flynn. (2001) Crystal structure of an aldehyde reductase Y50F mutant-NADP complex and its implications for substrate binding. Proteins, 44, 12-19.

65) C.M. Hosfield, T. Moldoveanu, P.L. Davies, J.S. Elce and Z. Jia. (2001) Calpain mutants with increased Ca2+-sensitivity and implications for the role of the C2-like domain III. J. Biol. Chem. 276, 7404-7407.

64) Z. Jia, V. Petrounevitch, A. Wong, T. Moldoveanu, P.L. Davies, J.S. Elce and J.S. Beckmann. (2001) Mutations in calpain 3 associated with limb girdle muscular dystrophy: Analysis by molecular modelling and by mutation in m-calpain. Biophys. J. 80, 2590-2596.

63) M.N. Rahman, V. Petrounevitch, Z. Jia and M.L. Koschinsky. (2001) Antifibrinolytic effect of single apo(a) kringle domains: Relationship to fibrinogen binding. Protein Eng. 14, 427-438.

62) S.P. Graether and Z. Jia. (2001) Modeling Pseudomonas syringe ice-nucleation protein as a b-helical protein. Biophys. J. 80, 1169-1173.

61) Q. Ye, D. Hyndman, N. Green, X. Li, Z. Jia and T.G. Flynn. (2001) The crystal structure of an aldehyde reductase Y50F mutant-NADP complex and its implications for substrate binding. Chem. Biol. Interact. 130-132, 651-658.

60) T. Moldoveanu, C.M. Hosfield, Z. Jia, J.S. Elce and P.L. Davies. (2001) Ca2+-induced structural changes in rat m-calpain revealed by partial proteolysis. Biochim. Biophys. Acta 1545, 245-254.

59) Z. Chen, T. Moyana, A. Saxena, R. Warrington, Z. Jia and J. Xiang. (2001) Efficient antitumor immunity derived from maturation of dendritic cells that had phagocytosed apoptotic/necrotic tumor cells. Int. J. Cancer. 93, 539-548.

58) V.K. Walker, M.J. Kuiper, M.G. Tyshenko, D. Doucet, S.P. Graether, Y.-C. Liou, B.D. Sykes, Z. Jia, P.L. Davies and L.A. Graham. (2001) Surviving winter with antifreeze proteins: Studies on budworm and beetles. In Insect Timing: Circadian Rhythmicity and Seasonality (Denlinger, Giebultowicz and Saunders, Eds.), pp. 199-211, Elsevier Science, Amsterdam.

57) Z. Jia, M. Cottrill, G.P. Pal, D. Lee, M. Sung, C.W. Forsberg and J.P. Phillips (2001). Purification, crystallization and preliminary X-ray analysis of the Escherichia coli glucose-1-phosphatase. Acta Cryst. D57, 314-316.

56) Z. Jia. (2001) Structural studies of E. coli phytase and its complex with phytate. Recent Res. Devel. Protein Eng. 1, 291-301.


55) Y.-C. Liou, A. Tocilj, P.L. Davies and Z. Jia. (2000) Mimicry of ice structure by surface hydroxyls and water of a b-helix antifreeze protein. Nature, 406, 322-324.

54) S.P. Graether, M.J. Kuiper, S.M. Gagne, V.K. Walker, Z. Jia, B.D. Sykes and P.L. Davies. (2000) b-Helix structure and ice-binding properties of a hyperactive insect antifreeze protein. Nature, 406, 325-328.

53) R. Bell, W.K. Stevens, Z. Jia, J. Samis, H.C.F. Cote, R.T.A. MacGillivray and M.E. Nesheim. (2000) Fluorescence properties and functional roles of tryptophan residues 60d, 96, 148, 207, and 215 of thrombin. J. Biol. Chem. 275, 29513-29520.

52) D. Lim, S. Golovan, C.W. Forsberg and Z. Jia. (2000) Crystal structures of Escherichia coli phytase and its complex with phytate. Nat. Struct. Biol. 7, 108-113.

51) J. Xiang, M. Srivamadevan, J. Yang and Z. Jia. (2000) Study of B72.3 combining-sites by molecular modelling and site-directed mutagenesis. Protein Eng. 13, 339-344.

50) Y.-C. Liou, P.L. Davies and Z. Jia. (2000) Crystallization and preliminary X-ray analysis of insect antifreeze protein from the beetle, Tenebrio molitor. Acta Cryst. D56, 354-356.

49) P.S. David, P.S. Dutt, C.B. Wathen, Z. Jia and B.C. Hill. (2000) Characterization of a structural model of membrane bound cytochrome c-550 from Bacillus subtilis. Arch. Biochem. Biophys. 377, 22-30.

48) Q. Ye, X. Li, D. Hyndman, T.G. Flynn and Z. Jia. (2000) Crystal structure of CHO reductase, a member of the aldo-keto reductase superfamily. Proteins, 38, 41-48.


47) C.M. Hosfield, J.S. Elce, P.L. Davies and Z. Jia. (1999) Crystal structure of calpain reveals the structural basis for Ca2+-dependent protease activity and a novel mode of enzyme activation. EMBO J. 18, 6880-6889.

46) S.P. Graether, C.I. DeLuca, J. Baardsnes, G.A. Hill, P.L. Davies and Z. Jia. (1999) Quantitative and qualitative analysis of type III antifreeze protein structure and function. J. Biol. Chem. 274, 11842-11847.

45) M.L. Tejada, Z. Jia and R.G. Deeley. (1999) Determinants of DNA-binding specificity in the avian homeodomain protein, AKR. DNA Cell Biol. 18, 791-804.

44) G. Chen and Z. Jia. (1999) Ice-binding surface of fish type III antifreeze. Biophys. J. 77, 1602-1608.

43) C.M. Hosfield, Q. Ye, J.S.C. Arthur, C. Hegadorn, D.E. Croall, J.S. Elce and Z. Jia. (1999) Crystallization and X-ray crystallographic analysis of m-calpain: A Ca2+-dependent protease. Acta Cryst. D55, 1484-1486.

42) J. Xiang, L. Prasad, L.T.J. Delbaere and Z. Jia. (1999) Light-chain FR residue Tyr71 of chimeric B72.3 antibody plays an important role in influencing TAG72 antigen binding. Protein Eng. 12, 417-421.

41) J. Yang, Z. Jia and J. Xiang. (1999) Substitution of surface-exposed framework residues alters secretion of recombinant fusion protein FV/TNF in Escherichia coli. IUBMB Life, 48, 327-332.

40) A. Cole, R. Zirngibl, A. Craig, Z. Jia and P. Greer. (1999) Mutation of a highly conserved aspartate residue in subdomain IX abolishes Fer protein-tyrosine kinase activity. Protein Eng. 12, 155-162.

39) D. Lim, Q. Ye and Z. Jia (1999) Condensation-free X-ray diffraction data collection with capillaries at 277 K. J. Appl. Crystallogr. 32, 134-135.

38) S.P. Graether, Q. Ye, P.L. Davies and Z. Jia. (1999) Crystallization and preliminary X-ray crystallographic analysis of spruce budworm antifreeze protein. J. Struct. Biol. 126, 72-75.


37) Q. Ye, E. Leinala and Z. Jia. (1998) Crystal structure of type III antifreeze protein at 4°C. Acta Cryst. D54, 700-702.

36) M. Rahman, Z. Jia, B.R. Gabel, S.M. Marcovina and M.L. Koschinsky. (1998) Expression of apo(a) kringle IV type 9 in E. coli: Determination of a specific interaction between kringle IV type 9 and apoB-100. Protein Eng. 12, 1249-1256.

35) K.J. Rees-Milton, Z. Jia, N.C. Green, M. Bhatia, O.El-Kabbani and T.G. Flynn. (1998) Aldehyde reductase: The role of the C-terminal residues in defining substrate and cofactor specificities. Arch. Biochem. Biophys. 355, 137-144.

34) R.J. Hodgson, Z. Jia and W.C. Plaxton. (1998) A fluorescence study of ligand-induced conformational change in cytosolic fructose-1,6-bisphophatase from germinating castor oil seeds. Biochim. Biophys. Acta. 1388, 285-294.

33) G. Huyer, J. Kelly, J. Moffat, R. Zamboni, Z. Jia, M.J. Gresser and C. Ramachandran. (1998) Affinity selection from peptide libraries to determine substrate specificity of protein tyrosine phosphatases. Anal. Biochem. 258, 19-30.

32) S. Desmarias, Z. Jia and C. Ramachandran. (1998) Inhibition of protein tyrosine phosphatases PTP1B and CD45 by sulfotyrosyl peptides. Arch. Biochem. Biophys. 354, 225-231.

31) J.W. Quail, J. Yang, P. Schneider and Z. Jia. (1998) Crystal structure of the Rhizomucor miehei aspartic proteinase. Adv. Exp. Med. Biol. 436, 283-292.

30) C.I. DeLuca, P.L. Davies, Q. Ye and Z. Jia. (1998) The effects of steric mutations on the structure of type III antifreeze protein and its interaction with ice. J. Mol. Biol. 275, 515-525.

29) Z. Jia, S. Golovan, Q. Ye and C.W. Forsberg. (1998) Purification, crystallization and preliminary X-ray analysis of the Escherichia coli phytase. Acta Cryst. D54, 647-649.


28) Z. Jia. (1997) Protein phosphatases: structures and implications. Biochem. Cell Biol. 75, 17-26.

27) J. Yang, J.W. Quail and Z. Jia. (1997) Succinyl oleanolic acid. Acta Cryst. C53, 349-351.


26) Z. Jia, C.L. DeLuca, H. Chao and P.L. Davies. (1996) Structural basis for the binding of a globular antifreeze protein to ice. Nature, 384, 285-288.

25) T.R. Burke, Jr., B. Ye, X. Yan, S. Wang, Z. Jia, L. Chen, Z.-Y. Zhang and D. Barford. (1996) Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor design. Biochemistry, 35, 15989-15996.


24) Z. Jia, D. Barford, A.J. Flint and N.K. Tonks. (1995) Structural basis for phosphotyrosine peptide recognition by human protein phosphatase 1B. Science, 268, 1754-1758.

23) D. Barford, Z. Jia and N.K. Tonks. (1995) Protein tyrosine phosphatases take off. Nat. Struct. Biol. 2, 1043-1053.

22) J. Xiang, Y. Sha, Z. Jia, L. Prasad and L.T.J. Delbaere. (1995) Framework residues 71 and 93 of the chimeric B72.3 antibody are major determinants of the conformation of heavy-chain hypervariable loops. J. Mol. Biol. 253, 385-390.

21) Z. Jia. C.I. DeLuca and P.L. Davies. (1995) Crystallization and preliminary X-ray crystallographic studies on type III antifreeze protein. Protein Sci. 4, 1236-1238.

20) Z. Jia, S. Hasnain, T. Hirama, X. Lee, R. To and C.P. Huber. (1995) Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex: Implication for structure-based inhibitor design. J. Biol. Chem. 270, 5527-5533.

19) Z. Jia, L.N. Johnson (1995) Learning modern protein crystallography. Structure, 3:125.


18) Z. Jia, M. Vandonselaar, P. Schneider and J.W. Quail. (1994) Crystallization and preliminary X-ray structure solution of Rhizomucor miehei aspartic proteinase. Acta Cryst. D51, 243-244.

17) T.V. Brennan, J.W. Anderson, Z. Jia, E.B. Waygood and S. Clarke. (1994) Repair of spontaneously deamidated HPr phosphocarrier protein catalyzed by the L-isoaspartate-(D-aspartate) O-methyltransferase. J. Biol. Chem. 269, 24586-24595.

16) Z. Jia, J.W. Quail, L.T.J. Delbaere and E.B. Waygood. (1994) Structural comparison of histidine-containing phosphocarrier protein HPr. Biochem. Cell Biol. 72, 202-217.

15) Z. Jia, M. Vandonselaar, W. Hengstenberg, J.W. Quail and L.T.J. Delbaere. (1994) The 1.6 Å resolution structure of histidine-containing phosphocarrier protein HPr from Streptococcus faecalis. J. Mol. Biol. 236, 1341-1355.


13) Z. Jia, M. Vandonselaar, J.W. Quail and L.T.J. Delbaere. (1993) Active-centre torsion-angle strain revealed in 1.6 Å resolution structure of the histidine-containing phosphocarrier protein. Nature, 361, 94-97.

14) Z. Jia, E.B. Waygood, J.W. Quail and L.T.J. Delbaere. (1993) The 2.0 Å resolution structure of Escherichia coli histidine-containing phosphocarrier protein HPr. J. Biol. Chem. 268, 22490-22501.


12) J.R. Dimmock, K.M. Advikolanu, H.E. Scott, M.J. Duffy, R.S. Reid, J.W. Quail, Z. Jia, R.A. Hickie, T.M. Allen, J.M. Rutledge, M.L. Tempest and A.B. Oreski. (1992) Cytotoxicity evaluation of some mannich bases of various aryl and arylidene ketones and their corresponding arylhydrazones. J. Pharm. Sci. 81, 1147-1152.

11) J.R. Dimmock, K.K. Sidhu, J.W. Quail, Z. Jia, M.J. Duffy, R.S. Reid, D.L. Kirkpatrick, L. Zhu and S.M. Fletcher. (1992) Synthesis and cytotoxic evaluation of some 6-arylidene-2-(a-hydroxyamino-a-aryl-methyl)cyclohexanone oximes and related compounds. J. Pharm. Sci. 81, 1059-1064.

10) S. Gupta, P.J. Aduma, Z. Jia, A.L. Stuart, S.A. Kumar, G. Tourigny, and L.T.J. Delbaere. (1992) Relationship between conformation and antiviral activity - II. 5-methoxymethyl-2'-deoxycytidine and 5-methoxymethyl-N4-methyl-2'-deoxycytidine. Antivir. Chem. Chemoth. 3, 15-22.


9) Z. Jia, G. Tourigny, A.L. Stuart, L.T.J. Delbaere and S.V. Gupta. (1990) Structure and conformation of 5-methoxymethyl-2'-deoxycytidine. Can. J. Chem. 68, 836-841.

8) Z. Jia, J.W. Quail and J.R. Dimmock. (1990) Structure of 2-(4-dimethylaminobenzylidene)-cyclohexanone. Acta Cryst. C46, 2467-2468.

7) Z. Jia, G. Tourigny, A.L. Stuart, L.T.J. Delbaere and V.S. Gupta. (1990) Structure and conformation of 5-methoxymethyl-N4-methyl-2'-deoxycytidine. Acta Cryst. C45, 2182-2185.

6) J. R. Dimmock, V.K. Arora, S.L. Wonko, N.W. Hamon, J.W. Quail, Z. Jia, R.C. Warrington, W.D. Fang and J.S. Lee. (1990) 3,5-bis-benzylidene-4-piperidones and related compounds with high activity towards P388 leukemia cells. Drug Des. Deliv. 6, 183-194.


5) M.S.C. Pedras, S.R. Abrams, G. Seguin-Swartz, J.W. Quail and Z. Jia. (1989) Phomalirazine, a novel toxin from the phytopathogenic fungus Phoma lingam. J. Am. Chem. Soc. 111, 1904-1905.

4) Z. Jia, J.W. Quail, V.K. Arora and J.R. Dimmock. (1989) Structure of 3,5-bis(benzylidene)-1-methyl-4-piperidone methobromide hemiethanol solvate. Acta Cryst. C45, 1117-1118.

3) Z. Jia, J.W. Quail, V.K. Arora and J.R. Dimmock. (1989) Structure of 3,5-bis(4-dimethyl-aminobenzylidene)-1-methyl-4-piperidone methoiodide. Acta Cryst. C45, 1119-1120.

2) Z. Jia, J.W. Quail, V.K. Arora and J.R. Dimmock. (1989) Structures of 2,6-bis(benzylidene)-cyclohexanone (III) and  3,5-(4-dimethylaminobenzylidene)-1-methyl-4-piperidone (IV). Acta Cryst. C45, 285-289.


1) Z. Jia, J.W. Quail, V.K. Arora and J.R. Dimmock (1988) Structures of 3,5-bis(benzylidene)-4-piperidone hydrochloride (I) and its N-methyl analog (II). Acta Cryst. C44, 2114-2117.


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